Electrolytes in water used for the poreparation of dialysis fluid

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Electrolytes in water used for the poreparation of dialysis fluid

nhoenich
At the recently held ART meeting I gave a talk on current and future standards for water and dialysis fluid. There is a proposal to reduce the permitted levels of electrolytes in the water used for the preparation of dialysis fluid. (See Table below) Sodium 70 (3,0 mmol/L) reduced to 50 (2,2 mmol/L) Potassium 8 (0,2 mmol/L) reduced to 2 (0,05 mmol/L) Magnesium 4 (0,15 mmol/L) reduced to 1 (0,04 mmol/L) Calcium 2 (0,05 mmol/L) no change proposed The thinking behind the proposals is as follows: Sodium: This revision ensures that the contribution of dialysis water to the final dialysis fluid remains minimal, specifically well below 2.5% of the typical sodium concentration in the dialysis fluid. Potassium: This revision ensures that the contribution of dialysis water to the final dialysis fluid remains minimal, i.e., ≤ 5% of the typical potassium concentration in the dialysis fluid. Magnesium: This revision ensures that the contribution of dialysis water to the final dialysis fluid remains minimal, i.e., ≤ 5% of the typical potassium concentration in the dialysis fluid In addition, the revision corrects a chemical inconsistency in the previous limit: in natural water, calcium typically exceeds magnesium in concentration, with a Ca:Mg ratio of approximately 3:1. Therefore, the previous limit of 4 mg/l for magnesium compared to 2 mg/l for calcium did not reflect the typical balance found in water hardness and lacked chemical justification. I would appreciate the views of technologists concerning this proposal in order to establish if the suggested changes result in any issues , namely if you look at your incoming water to the water treatment system are the suggested values achievable on a routine basis? Many thanks Nh
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Re: Electrolytes in water used for the poreparation of dialysis fluid

Gareth Murcutt
Hi Nic,

I can see issues with achieving a level of 2mg/l for potassium. I also think we'd need to speak to labs re the proposed Mg level as many of our are currently reported as <1.5 mg/l.

I'll have a look through a few more historical results.
Best
Gareth
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Re: Electrolytes in water used for the poreparation of dialysis fluid

fraser gilmour
In reply to this post by nhoenich
As Gareth has said the current limit of detection for the renal suite re magnesium is 1.5mg/l. Our lab have confirmed it is technically possible to lower the LOD, but there would need to be a change to their operational policy which I assume would need UKAS certification. Probably quite a bit of work for all the labs to do this but I suppose they would have to if it's a customer requirement.
I don't see any problem with achieving any of the new limits in our area.